We are very proud to present the world premiere of BLUEBRAIN – Year One, a documentary short which previews director Noah Hutton’s 10-year film-in-the-making that will chronicle the progress of The Blue Brain Project, Henry Markram’s attempt to reverse-engineer a human brain. Enjoy the piece and let us know what you think.
The film is being produced by Noah Hutton’s production company, Couple 3 Films.




Must-see. Is 2020 the release date for the documentary, though, or the deadline for the project?
Thanks Max – Markram’s estimate is that he’ll have a full human brain built in ten years, so however long it takes, that’s how long it’ll take to make this film.
Awesome. I think this is the most exciting project in all of neuroscience, and Markram enumerated the reasons why much better here than I have seen him do in other places, such as his TED talk.
Did you ever discuss ethical issues about the project, such as the ethical implications of simulating a functioning human brain down to the molecular level and what rights that simulated brain would have? I could see the project becoming very controversial when it progresses to that stage.
What other parts of the body (such as motor nerves, the retina, etc) will you have to simulate so that the simulated brain can interact with an environment? Do they intend to set up the brain to control a virtual body in a virtual world or a real robotic body in real life?
Where do you draw the line between a simulation of a brain and an authentic brain?
Speaking of connections between science and art, I’m reminded of a short story by Jorge Luis Borges, “Of Exactitude in Science:”
In that Empire, the craft of Cartography attained such Perfection that the Map of a Single province covered the space of an entire City, and the Map of the Empire itself an entire Province. In the course of Time, these Extensive maps were found somehow wanting, and so the College of Cartographers evolved a Map of the Empire that was of the same Scale as the Empire and that coincided with it point for point. Less attentive to the Study of Cartography, succeeding Generations came to judge a map of such Magnitude cumbersome, and, not without Irreverence, they abandoned it to the Rigours of sun and Rain. In the western Deserts, tattered Fragments of the Map are still to be found, Sheltering an occasional Beast or beggar; in the whole Nation, no other relic is left of the Discipline of Geography.
Thanks a lot for watching and for your comments Eric. I spoke briefly with Markram about some ethical issues but it was a bit too much to get all that into this first piece. The short of it is that he believes this technology itself is not inherently dangerous– but it can be intentionally used in a dangerous way. In terms of human rights for this brain… that will be good material for a future interview, so thanks for bringing that up.
They intend to scale the model up from a rodent brain (which is the current work being done), to a cat brain, to a primate brain, and finally to a human brain, each time using an avatar in a virtual environment that will be controlled by the Blue Brain. We didn’t get into specifics of what parts of the peripheral nervous system they’ll be simulating, and what they’ll do about visual input. It is interesting to think about where the neurons end and the pure digital data from the virtual environment would begin and how sensory input is to be handled.
Thanks for those thoughts and for the great Borges excerpt. My hope in posting these ongoing segments from this project will be to get this kind of feedback that will help to shape the film and address important avenues of future questioning, so it’s great to hear from you about all this.
This is terrifyingly amazing. I really don’t know whether to be excited or afraid of the possibilities this could open up for mankind. It would be great for solving brain anomalies, but I know it won’t stop there. It’s so interesting though that I don’t want it to stop.
The photographs are lovely, like Jackson Pollock paintings, but I’m reminded of lyrics from a Leonard Cohen song:
“…they’ll never ever reach the moon,
at least not the one that we’re after;
it’s floating broken on the open sea, look out there, my friends,
and it carries no survivors.
But lets leave these lovers wondering
why they cannot have each other…”
Still, the Bluebrain experiment seems more worthy than some of Nasa’s projects, equally expensive. Yet again, the black boxes the brain is currently housed in look very much like those on the moon at the beginning of the movie “2001, A Space Odyssey.”
Agreed. I also had the “2001, A Space Odyssey” reaction.
Noah,
This is truly incredible! How can I post this to my facebook to let people know about it??? Jen
I watched your video because your dad posted it on twitter. I think not only is it very awesome you have a father that supports your work and gifts but also wow, Noah Hutton, you are brilliant at film making.
Your video flowed very well and I really enjoyed watching it even though I don’t know much about the brain.
I like making videos as well, but my videos are for churches who want to spread God’s word visually. Making films is so rewarding. I love everything about it. So, it’s nice to meet you Noah. Keep up the good work and I hope to see more of your videos in the future.
This project is another example how we can work together to help others. The brain modeling is intriguing and may lead to many breakthroughs for mankind. I look forward to future updates. As the world gets smaller, this is one area of discovery for those explorers out there.
An extremely interesting subject and project. I’ve always been fascinated with how we think the way we do, why some individuals are smarter than others etc. and as the daughter of a parent with Alzheimers and the spouse of a depressive (especially appreciate Dr. Markham’s remark about pills); I am hopeful that his progress towards a better understanding of the brain’s functions and processes will be beneficial in resolving some of these types of issues.
Mr. Hutton’s initial opening shots are beautiful, the office tour by the Project Manager seems a bit choppy but I totally love his choice of backround music. Hope there will be further “updates” on this film/documentary.
interesting trailer,
quite like the music what is it?
thanks
The opening music is Miles Davis’ “It Ain’t Necessarily So” from Porgy and Bess and the longer piece for the rest is from Terry Riley’s “In C”
Thanks for watching.
Strange. I was quite bothered by the suspenseful music – I kept thinking, what, is a terrorist going to leap out of his desk drawers?
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Thanks Noah, I think that it’s a great idea to follow this amazing project till its successful end.
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In the article “Out Of The Blue” on the Seed magazine (from 2008) it was said that Hanry Markram is planning to connect the Blue Brain with a virtual or robotic body and see if it’s acting like a real rat, I think that this is a very efficient way to see if the model is built correctly or not:
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http://seedmagazine.com/content/article/out_of_the_blue
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“Henry Markram is talking to a Japanese company about constructing the mechanical animal…. If the robotic rat just bumps into walls, then we’ve got a problem…. Installing Blue Brain in a robot will also allow it to develop like a real rat. The simulated cells will be shaped by their own sensations, constantly revising their connections based upon the rat’s experiences. What you ultimately want is a robot that’s a little bit unpredictable, that doesn’t just do what we tell it to do, the goal is to build a virtual animal—a rodent robot—with a mind of its own”
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Also on another article on the BBC news it was said that “The Blue Brain has been put in a virtual body, and observing it gives the first indications of the molecular and neural basis of thought and memory”
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http://news.bbc.co.uk/2/hi/sci/tech/8012496.stm
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I didn’t see any reference to this interesting issue in your movie, didn’t he say anything about it? how does their virtual rat acting? what tests are they doing with it and how does the results fits with the same tests performing with a real rats?
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Please let me know if you have any information about this becouse it’s really sounds very interesting, and I can’t find any information about it on the net.
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Thanks.
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Thanks for your question. He talks about this issue at 10:15 in the video. They haven’t done it yet, but the team plans to connect the Blue Brain to an avatar in a virtual environment to collect sensory experience, and to be controlled by the Blue Brain. They’ll do this first with a rat.
Thanks Noah, you right I miised that, but that’s very strange, becouse in the BBC article which is from April 2009 Henry Markram said that they already done it “The Blue Brain has been put in a virtual body, and observing it gives the first indications of the molecular and neural basis of thought and memory…… the column is being integrated into a virtual reality agent – a simulated animal in a simulated environment, so that the researchers will be able to observe the detailed activities in the column as the animal moves around the space…… It starts to learn things and starts to remember things…..”
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http://news.bbc.co.uk/2/hi/sci/tech/8012496.stm
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It sounds as they already done that.
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That’s strange.
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Check this 2 Astonishing lectures of Henry Markram:
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http://neuroinformatics2008.org/congress-movies/Henry%20Markram.flv/view
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http://ditwww.epfl.ch/cgi-perl/EPFLTV/home.pl?page=start_video&lang=2&connected=0&id=365&video_type=10&win_close=0
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Very interesting article from the ‘Seed’ magazine:
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http://seedmagazine.com/content/article/out_of_the_blue
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http://seedmagazine.com/content/article/out_of_the_blue/P2
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And a few more interesting links about the project:
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http://news.bbc.co.uk/2/hi/sci/tech/8012496.stm
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http://www.youtube.com/watch?v=Bz5IUaRr8No
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http://www.youtube.com/watch?v=RLCT3wU4fek
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Fantastic stuff. This is quite an ambitious project. A Sisyphusian (or Fitzcarraldo-ian) task, if you will.
Dr. Markram’s eyes are interesting to watch in his interview. Very blue – which goes well with his ‘blue brain’ title. And I thought that his reaction to your question ‘how do you carry on?’ is great, and very telling.
I have a billion questions about the project itself, especially since this stuff is way beyond my payscale. But the one that I keep coming back to is:
What about the plasticity of the brain? I think of the brain as something that’s constantly moving and changing and evolving and adapting, based on what the brain is actually being used for. Right? The human brain is a product of years and years of decisions and experiences and neural ‘habits’ and so forth. Because we think a certain way or respond a certain way to outside stimulii, we groove out certain neural pathways and smooth out others.
Maybe another way of saying this is that our brain ‘hardware’, in addition to informing our behavior, also changes as a RESULT of our behavior (isn’t this the argument behind fields like epigenetics?). How would a reverse-engineered brain compensate for this time-factor. Would it “mature”, would it develop “habits” based on the tests we ran on it? Or would it remain the same depending on which data we tried to run through it’s system?
Maybe I’m way off the mark here with the actual science, but I just thought I’d throw this idea out there.
Hi Jeremy, did you check the links in my last comment? did you see the 2 lectures of Henry Markram? I think that you will find there most of the answers to your questions, the Blue Brain is also very plastic just like your brain, and it planned to learn new things just like your brain, one option will be to turn it on and to start learning it things, like a baby, OR, it should be possible to put inside the simulation data that was scaned from a grown up person, so that when you will turn the simulation on it will right away start acting like a grown up person.
Wow! Thanks for the response.
I’m even more baffled now by the project.
I did not click the links yet, but I’ll do so right now, in hopes that I can figure out exactly how it’s going to work…
Hi Jeremy, I don’t want to confuse you, when I sent the links I sent them under the username “Smart Brain”. I recommended that you will see the 2 lectures of Henry Markram first, they are really amazing, and have lot of information about the project, then check the article from the ‘Seed’ magazine, then check the other links.
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Please tell me if you have any questions about this subject.
Amazing work Henry! Is Rod Douglas involved in this as well? Just yesterday I was looking at a picture of Neil, Laurie, Barry, me and you at Clanwilliam Dam and here you are at the forefront of neuroscience where you belong!
Will be watching this space closely.
Best wishes
Jim Abrahams
Sorry for asking, but who is Rod Douglas? and who are Neil, Laurie, Barry and you? are your involving in a brain research? can you give here a link to this picture? do you know Henry Markram in real life?
I don’t think there is a subject more fascinating, so I’m excited to follow their progress via this documentary. However, please find different background music. It’s VERY annoying, and I kept wishing that I could turn it off.
Paton,
Sorry to hear you found the music annoying– the piece is Terry Riley’s “In C” and for now it’s just a placeholder– I’ll be composing the score for the full-length documentary once it’s done in ten years (or whenever Markram finishes). Here are some songs I’ve composed: http://www.couple3.com/main/music/
Thanks for watching.
Fascinating. Great work, Noah.