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Neuroscience Rock Music, Snake Charmers, and More

[ 1 ] September 24, 2010

This weekend, as part of World Maker Faire, TalkingScience will present three performances of the Rock-It Science Cabaret, a science variety show featuring scientists and performers illustrating principles of physics, chemistry, and biology.

Ira Flatow, host of NPR’s live news/talk show Science Friday, will introduce the Rock-It Science Cabaret, and will be available at Science Friday’s booth at Maker Faire to meet and talk to fans after he leaves the Science Stage on Saturday.

Each of the Rock-It Science Cabaret’s three performances will feature a different program, with acts including:

  • Brainy music by The Amygdaloids, NYU neuroscientists led by Joseph LeDoux who sing about how the inside of your head works (Special note: Beautiful Brain editor Noah Hutton will be sitting in on drums for the Amygdaloids on Saturday)
  • Serpentina the Snake Charmer from Coney Island, who can show you how to make friends with big snakes;
  • Incredible science demos that you can take part in;
  • Science punk rock, green rap music, and more.


    Saturday, September 25, 2010, noon and 4:00 PM  – rain or shine.

    Sunday, September 26, 2010, 1:00 PM – rain or shine


    The New York Hall of Science, 47-01 111th Street in Queens, NY

    Thinking About Thinking

    [ 1 ] September 20, 2010

    In a new article in Science, a group of researchers led by Geraint Rees from University College London, suggest they have a found a neural correlate for introspection.  The region of interest is the anterior prefrontal cortex of the brain, which is also implicated in other higher cognitive behaviors like planning, decision-making, social intelligence, and determining predicted outcomes of one’s actions [it is the frontal cortex that was damaged in the infamous case of Phineas Gage].

    “Introspection” was measured by having people answer a tough question, and subsequently measure how the result of their answer (right vs wrong) affected their confidence in their own decision making in a series of follow up questions.  More introspection meant a correlation between the result of their early answers to their confidence in later ones; in a sense, introspection is the meta-analysis of one’s own thoughts.  FMRI data showed that increased gray matter volume in the prefrontal cortex was correlated with high levels of introspection.



    [ 0 ] September 11, 2010

    Dopamine is a key neurotransmitter released in our brains when we do something rewarding. The dopaminergic system is behind most good feelings we have, and it is also the chemical that is targeted by highly addictive drugs such as cocaine.

    To create this beautiful micrograph of dopamine crystals, Spike Walker, who won Thursday evening’s Royal Photographic Society‘s Combined Royal Colleges Medal, shone polarized light at the minute chemical structures. The crystals reflect light at different wavelengths depending on their orientations within the overall chemical structure. According to Walker, using this technique highlights more detail in the crystal structure than regular observation through a microscope.


    [ 7 ] September 7, 2010

    Courtesy of my favorite hip-hop blog, 2DOPEBOYZ comes a unique track from rapper Prince Ea, a St. Louis-born University of Missouri student.  The track is called “The Brain,” and features Ea (pronounced “E”) performing “a lyrical look into the three-pound organ between the ears and behind the eyes.”  Pretty impressive for the young MC.  I look forward to hearing more of Prince Ea’s rhymes about science.
    Here’s a link to download.

    Motor Learning and the Cerebellum

    [ 4 ] September 3, 2010

    Some new research just came out in Neuron that is incredibly relevant to the work I do in my lab.  The myriad (billions) of granule cells in the cerebellum send their axons, the parallel fibers, to the purkinje cells (pictured below).  This junction is of utmost importance…excitation of purkinje cells leads to the inhibition of behavior, whereas as inhibition of the purkinje cells generally leads to motor movement.  While common sense and many experiments have shown that movement-inducing inhibition of the purkinje cells (called “Long-Term Depression,” or LTD) is vital for motor learning, new research like this points towards the role of excitation of the purkinje cells (called “Long-Term Potentiation,” or LTP), and thus inhibition of motor behavior, as well.  I study motor learning in the Medina lab at Upenn, with a focus on the parallel fiber-purkinje cell synapse.  This research certainly adds more to the puzzle of motor learning…the mystery grows…

    Check out the “video abstract” at

    image/Ramon y Cajal

    The Importance of Neuron Diversity

    [ 1 ] August 31, 2010

    No two neurons are the same.  Even neurons of the same type (i.e. purkinje cells) behave differently.  This fact is often overlooked as an important functional feature of the brain, and instead chalked up to biological impreciseness.  In their recent Nature article, Krishnan Padmanabhan and Nathaniel Urban think there’s an important reason behind all the diversity.  They studied the “intrinsic differences” in the molecular signatures and firing behaviors of mitral cells in the mouse olfactory bulb, and by differentially stimulating different cells concluded that:

    Although a number of mechanisms have been proposed to account for the origin and extent of these intrinsic differences, we found that differences in intrinsic biophysical heterogeneity can be important [for] neural coding.

    In other words, the intrinsic differences between neurons are not biological mistakes – they are adaptive functions for the complex neural coding of stimulus information.

    100 billion neurons, and each one is functionally different?  I’m having trouble coding that one…

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