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The Sloan Film Summit

[ 0 ] October 30, 2011

Two things happened on the last Saturday in October.  The first snow of the season came.  That was the first thing that happened, and unfortunate too, because there’s a leak in the boiler in my building, so gas doesn’t have the necessary pressure to make it up five flights of pre-war pipes.  At least that’s what the super told me in Spanish while we stood in the clouded basement, two men sharing in the sacred ritual of the steam (albeit in an accidental sauna).  But never mind that, because there was the second thing: later that day I attended my first summit, a meeting of important people, for film and science.  When I was invited all I could conjure was Camp David and G-8—20, but, to my knowledge, there were no heads of state there at the Museum of the Moving Image in Queens.

Every 3 years The Sloan Film Summit gathers filmmakers from around the world to privately discuss the eco political future of our planet . . . wait . . . !  what I mean to say is they’ve all received financial grants from the Alfred P. Sloan Foundation for the creation of science-themed narratives for the lay public.  Directors who have previously participated in this program include Warner Herzog, Darren Aranofsky, and Julian Schnabel.  Presented by the Tribeca Film Institute, there were 70 attendees this year, filmmakers with projects at various developmental stages.

I saw a staged reading of seven screenplay excerpts, ranging from the historical to the hysterical.  Or both, in the cases of Noah Miller’s Project Alpha—about a 1979 parapsychology study featuring two full-of-shit teenage subjects—and Matthew Evans’ The Wizard of Sussex—about Charles Dawson and the “missing link” hoax of 1912.  The staged reading itself is the real transitional form, a display of work on the way from page to screen.  It was cool to be able to observe these midway moments in the development of films.

Next was a delightful panel—”From Science to Fiction”—featuring scientists Dr. Janna Levin and Dr. Stuart Firestein alongside three filmmakers.  I found out that after graduate students show professors their data, the professor will often say “So what’s the story here?”  Results are even re-organized superficially for the sake of making sense, at which point scientists can realize that they’re “missing a scene,” maybe, and so they go back and conduct another experiment.  Sounds familiar, because scientists and artists are both creative problem-solvers.  Their methods may differ, but any human being striving for discovery, striving for anything, has inherent drama.  It’s the job of Sloan grantees to erase, hover over, or fancy-foot across and back from whatever arbitrary lines might separate an audience from material.

Now for a true story of my own, one funny to me: I am sitting in the hospitality room at the summit drinking straight half-and-half that’s supposed to be for coffee, when in comes a caravan of caterers each wearing one latex glove and holding up a tray of assorted chocolate cookies as though they’re grapes for Cleopatra.  Milk, then cookies?  A formal logical fallacy I recognize as “affirming the consequent,” necessarily false.  I’m a little giddy because logic seems to have been trumped, and so I say to one caterer “Thanks dude!  You baked all of those cookies yourself?” and he looked right at me and gave me just the answer, nothing more: “No, I didn’t.”  I read his face, it was like the face of a lay man reading to a dense scientific abstract.

The Alfred P. Sloan Foundation is not dedicated to studying the phenomenon of why everyone doesn’t always laugh at every single one of my jokes.  The Sloan Foundation—through it’s Program for Public Understanding of Science and Technology—is dedicated to educating and engaging the public with science-themed books, radio, public and commercial television and film, theater, the Internet, and new media.  They’re distributing $10 million this year through all phases of the creative process, from commission to distribution.  I had the pleasure of chatting with Doron Weber, who runs the program, and he told me that in his 15 years he has seen science distilled more-and-more successfully into the mainstream.  There are 4 Sloan-supported feature films being released, and many more coming down the pipe.

Which leads me to a serious question: Would the Sloan Foundation pay for space heaters in my apartment, if I called them spacetime thermodynamos and wrote a story about it?  Because I’m working on it, in layers.

Bluebrain | Year Two

[ 14 ] August 25, 2011

We are proud to present the Year Two update to director Noah Hutton’s 10-year film-in-the-making that will chronicle the progress of The Blue Brain Project, Henry Markram’s attempt to reverse-engineer the brain, culminating in a documentary feature in 2020. If you haven’t seen Year One, you can watch that here. Enjoy the piece and let us know what you think.

The film is being produced by Noah Hutton’s production company, Couple 3.

A Public Coversation about Morality and the Brain

[ 1 ] April 8, 2011

Patricia Churchland

It had been some time since I had sat in a university lecture hall.  But on March 30, a special event brought me to historic Havemeyer at Columbia University.  The topic: morality and the brain.  Patricia Churchland, whose research focuses on the interface between philosophy and neuroscience, offered answers to such unanswerable questions such as Can science tell us right from wrong? and Where do values come from? Dr. Churchland’s compelling and scrupulous theory — which takes into account evolutionary, genetic, neuroendocrinological, and behavioral evidence — appears in her new book, Braintrust (Princeton University Press).  An in-depth review of her argument will appear here at The Beautiful Brain soon.  Suffice it to say that it had also been some time since I had taken so many notes.

The greatly successful night was organized and sponsored by NeuWrite, a group of writers and scientists dedicated to the public dissemination of science, with support from the Dana Foundation.  Dr. Churchland’s presentation was followed by a dialogue with City University of New York philosopher Jesse Prinz, whose theoretical thinking is also tied to scientific study.  Churchland and Prinz might be called neurophilosophers, after Churchland’s 1989 book Neurophilosophy (The MIT Press).  These are the rare responsible intellectuals who will always have me happily stuck to my seat.

Life is a Dream

[ 3 ] March 25, 2011

Pedro Calderón de la Barca

Dreams are seemingly all anybody talks about in the Spanish Golden Age drama La vide es sueño (Life is a Dream).  In that classic by Pedro Calderón de la Barca, the crown prince of Poland — Segismundo — has been imprisoned by his father since birth because of a prophecy: Segismundo will be a cruel king.  But his father — King Basilio — wants to know whether or not his son is in fact cruel.  So Segismundo — now a man — is drugged, taken to the palace, and given the throne.  After waking up in power, he attempts to rape a woman, fights her father, and engages a duke in a duel.  A poor servant who points out the faults in Segismundo’s behavior is promptly thrown off of a balcony.  Now sure of the prophecy, King Basilio drugs his son again and returns him to captivity, where confused Segismundo wonders about reality:

What is life? A frenzy.

What is life?  An illusion,

a shadow, a fiction,

and the greatest good is mean:
for all life is a dream,

and dreams themselves are only dreams.

This is part of the most famous monologue in the play and whence its title comes. But after attending the March 20 Brainwave event with Debra Winger and Dr. Robert Stickgold, I re-discovered a brilliant speech by Clotaldo, the guard of Segismundo — and thought about it in the context of modern science:

But as they say dreams are rough copies of the waking soul

Yet uncorrected of the higher Will,

So that men sometimes in their dreams confess

An unsuspected, or forgotten, self;

One must beware to check — ay, if  one may,

Stifle ere born, such passion in ourselves

As makes, we see, such havoc with our sleep,

And ill reacts upon the waking day,

And, by the bye, for one test, Segismund,

Between such swearable realities —

Since Dreaming, Madness, Passion, are akin

In missing each that salutary rein

Of reason, and the guiding will of men.

Preeminent sleep researcher Dr. Stickgold — of Harvard Medical School and Beth Israel Deaconess Hospital — mentioned a fascinating finding: the prefrontal cortex, thought to be the throne of “executive function” — is particularly sensitive to sleep.  Its deactivation is responsible for the bizarreness of dreams.  Indeed, Clotaldo’s observation — philosophical in nature — is essentially the hypothesis that has been proven by sleep researchers (Trends in Cognitive Sciences, 2002).  Great minds think alike.

Next, Clotaldo describes the influence that dreams can have on waking life.  In a TedxRiverCity talk, Dr. Stickgold described an experiment by his student Erin Wamsley that showed that sleeping — and more specifically dreaming — improved performance on a task.  Subjects were required to navigate a 3-D maze.  In between trials, half of the subjects took 90-minute naps and half did not.  The nappers were on average one minute faster than non-nappers.  But the coolest finding was that the performance of the nappers who dreamed improved ten times.  It turns out that even off-topic dreams help.  (“A brief nap is beneficial for human route learning,” in press.)  The brain does not rest while the body does; in fact, the whole brain is busy processing information on multiple levels.  As Clotaldo notices, sleeping and waking are not strictly separate.  He does suggest that we should do our best to make them so, however.

Illustration by Jeremy Finch

Finally, Clotaldo draws a parallel between dreaming and two other states: madness and passion.  They are all born from a measure of freedom from the mainly rational self, which makes sure to say safe in order to survive in the world.  During the talk, Ms. Winger — Academy-Award nominated actress, author of the memoir/meditation Undiscovered, and mother of two sons — articulated her experience in the fluid continuum of dreaming and waking, and her frustration with quotidian concerns that keep her from that which is most deep and wonderful.  But all of the worlds — dreaming, and perhaps madness and passion too — are perpetually present.   Dreams do not “turn off,” Ms. Winger noted; the key is to access them while awake.  We might call that creativity.  Indeed, another finding related in the TedxRiverCity video showed that people who slept were two-and-a-half times more likely to perceive an underlying pattern in a memorized list of numbers.  Dr. Stickgold called this a “creative intrusion.”  He has said that he believes the purpose of dreams could be to integrate old and new memories and to imagine possible futures.  Is that not what an artist does?  And so we might add Creativity to Clotaldo’s list — with Madness, Passion, and, of course, Dreaming — of somewhat liberated mind-states.  Not intrusion, of course, but inspiration.  Pedro Calderón de la Barca must have known this.  You can read what his brain produced.

When they find out about their captive prince, the people of Poland liberate Segismundo and he becomes the head of a rebel force.  But he is reluctant to believe what is happening to him is real; he expects to again wake up from this dream of power.   Segismundo frees Clotaldo — who had tried to warm him about himself during the first kingship experiment— and acknowledges the importance of restraint.  Segismundo defeats his father, but mercifully lets him live.  He has a chance to satisfy his lust with the same woman, but does not.  Instead, he selflessly encourages the same dueling duke to marry her.  In the end, Segismundo becomes an enlightened king, devoted to acting well and doing good deeds.  All because of his powerful insight: life is a dream.  How fittingly Buddhist!

Brainwave 2011: Ride the Wave

[ 0 ] March 8, 2011

Brainwave 2011 | Illustration by Jeremy Finch

Shhh!  Listen.  Do you hear that?  That’s right ladies and gentlemen, the most enlightening conversation series in New York City is back.  Brainwave 2011!  At The Rubin Museum of Art.  The theme of this season is . . . DREAMS!

The first event that I had the pleasure of attending was “Who Dreamed the First Dream” (March 6), featuring the Israeli writer Meir Shalev and the American Museum of Natural History anthropologist Serinity Young.  Mr. Shalev—who writes a weekly column for the newspaper Yediot Ahronot—is the author of several fiction (A Pigeon and A Boy, 2006), non-fiction (In the Beginnings: Firsts in the Bible, 2011), and children’s books (My Father Always Embarrasses Me, 1988).  Dr. Young received a PhD in Comparative Religion and has edited and herself authored books, most notably Dreaming in the Lotus (1999), an analysis of the role of dreams in Buddhism, and the forthcoming Courtesans and Tantric Consorts: Sexualities in Buddhist Narrative, Ritual, and Iconography, which sounds pretty hot.

Dr. Young began by recounting the Buddhist myth of the dream of Queen Maya.  Queen Maya, the mother of the Buddha, dreamed that her womb was touched from the right side by a white elephant.  Wise men then concluded that Queen Maya would give birth to the Buddha.  Mr. Shalev remarked that this is very sexual.  The crowd laughed; he laughed too, but was at the same time quite serious.  “We cannot ignore the trunkiness of the trunk,” he reminded.  Mr. Shalev is also a wise man, and a gifted storyteller.  During his time onstage Mr. Shalev recounted his own childhood dreams and offered anecdotes about his father, which thoroughly delighted the audience.  In anticipation of Mr. Shalev’s talk, I was reading one of his books—The Blue Mountain (2002)—and it was delightful too, but unfortunately I got into a disagreement with it.  One of those “it’s not you it’s me” situations.  We’ll see what happens.  (If anyone is reading/has read the book and would like to council me through my relationship, feel free to get in touch.)

During the question-and-answer portion of the event, someone asked Mr. Shalev “Who is your favorite Bible character?”  Mr. Shalev said Jacob, because of the extreme poles—romantic and practical—that exist within his character.  For example, when Jacob first meets his wife-to-(eventually)-be Rachel, he notices that she is beautiful, and also that her family has a nice flock of sheep.  A good match, then, in two regards.  Mr. Shalev then remembered Paltiel, an even-less-than-minor character who appears for a few lines in the book of 2 Samuel.  We’re talking one-line-minor.  After overcoming the House of Saul, King David insists upon having Saul’s daughter Michal for a wife.  And so she was taken from her husband—Paltiel—who “went with her, weeping as he went, and followed her to Bahurim.  Then said Abner unto him, ‘Go, return’ and he returned’” (2Samuel3:16).  Devotion, loss.  There is a whole novel right there, as Mr. Shalev noted.  The Bible is filled with such unnoticed but necessary characters, which give the work the thorough richness that makes great literature great, as in for example The Iliad, War and Peace, The Inferno, Don Quixote, or Remembrance of Things Past.  Maybe the most telling thing about a person is how he treats his minor characters.  In art and in life.

March 6, 2011.  Brainwave.  I heard Mr. Meir Shalev.  To this point, he appears in maybe one line in the book of my life, if that were to exist.  He is a minor character.  And I am so grateful that I encountered him.  And I am grateful for Brainwave.  For its enrichment.

Science (and the Sexes) in the City

[ 1 ] March 7, 2011

Dr. Donald W. Pfaff

Last Tuesday evening approximately 100 people gathered at the New York Academy of Sciences to hear a talk on the neurobiology behind many of the sex differences found in men and women. The speaker was Dr. Donald W. Pfaff of Rockefeller University, well-known for his work in behavioral neuroscience and his studies on sex hormones.

Before the talk started, however, I was already impressed with the Academy’s presentation. Settling into a room boasting incredible Manhattan skyline views was a diverse group of individuals, all buzzing with excitement and anticipation for the event. Speaking with others I quickly concluded that this evening was drawing not only those interested in neuroscience, but those interested in women’s rights, autism, molecular biology, and numerous other relevant topics. Various ages and races abounded, and it was evident that this diverse group of people was brought together by a passion for information.

Dr. Pfaff, upon taking the podium, seemed as eager to provide this information as we were to receive it. The evening centered around the presentation of Dr. Pfaff’s recently published book “Man and Woman: An Inside Story of Neurobiology and Sex Differences.” He began the evening discussing the social implications of his work. The topic Dr. Pfaff will most likely receive high praise for is his “3 Hit Theory” of Autism Spectrum Disorders. Taking his cue from the 2 Hit Theory of cancer causation, Dr. Pfaff theorizes that in ASD there is not only the genetic and pre/neonatal stressors involved, but also androgenic hormones. These hormones can cause neuroanatomical sex differences which are controlled by the preoptic area in males and the medial basal hypothalamus in females. Males with ASD have been shown to have enlarged preoptic areas, presumably caused by an over absorption of testosterone in the prenatal period.

This led Dr. Pfaff into his next topic: the different ways in which he has been working with steroid hormone action. Much of Dr. Pfaff’s previous work has dealt with the absorption of hormones, and how this creates individual sex differences, or masculinization of the brain. During the administration of hormones one can simply raise hormone dosage, or they can raise tissue sensitivity, making hormone co-regulators more efficient. Dr. Pfaff introduced the possibility of “re-hooking” hormone responsive axons in order to make them more responsive to hormone absorption. This could make hormone therapy an easier ongoing process for individuals needing long-term treatment.

After this explanation, Dr. Pfaff, like a kid in a candy store, began to talk about new research he has done since the publication of his book; research on nucleosome remodeling. Dr. Pfaff’s research highlights that approximately 9% of the human brain contains nucleosomes which are specifically geared for sex differences. Through researching whether these nucleosomes continue to express gender differences at the genetic level throughout life, Dr. Pfaff began looking at the DNA around histone proteins. From this he has pinpointed how lysine and arginine can change inactive DNA into active nucleotides, which then allows estrogen dependent genes to turn on. This histone modification accounts for the sexual differentiation seen in the medial preoptic area for males, and the central medial hypothalamus in females. Future research can use these findings to better map specific genes which cause sex differences, and the period of development in which these genes are “on.”

After his talk Dr. Pfaff took questions, the nature of which again highlighted the diversity of the audience. Questions were asked about autism, women’s rights, and protein reproduction. Dr. Pfaff answered all to the best of his ability, and was generous enough to point people in the direction of his colleagues in order to better their understanding of anything he could not personally clarify. The evening hummed with a buzzing excitement of his findings, and I felt a sense of contentment that the study of sex differences is heading in directions that will help us better understand the opposite sex, as well as to help treat those with hormone maladies.

Kimberly Epperson is a full-time neuropsychology student in New York City who previously studied musical theater, and hopes to run a research clinic for mentally handicapped adolescents.

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